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Citalopram HBR


Citalopram has no or very reduced affinity for 5-HT1A, 5-HT2A, dopamine D1 as well as D2, α1-, α2-, as well as ß-adrenergic, histamine H1, gamma aminobutyric acid (GABA), muscarinic cholinergic, as well as benzodiazepine receptors. Antagonism of muscarinic, histaminergic and adrenergic receptors has been assumed to be associated with numerous anticholinergic, sedative, and cardio impacts of various other psychotropic drugs.

The solitary- and multiple-dose pharmacokinetics of citalopram are dose-proportional and also linear in a dose array of 10 to 60 mg/day. Biotransformation of citalopram is mostly hepatic, with a mean incurable half-life of concerning 35 hours. With daily dosing, constant state plasma focus are accomplished within about one week. At steady state, the level of build-up of citalopram in plasma, based on the half-life, is expected to be 2.5 times the plasma attentions noted after a solitary dosage. The tablet as well as dental remedy dosage kinds of citalopram hydrobromide are bioequivalent.

Complying with a solitary dental dosage (40 mg tablet) of citalopram, peak blood degrees happen at about 4 hours. The absolute bioavailability of citalopram had to do with 80 % about an intravenous dosage, as well as absorption is not had an effect on by food. The quantity of circulation of citalopram is regarding 12 L/kg as well as the binding of citalopram (CT), demethylcitalopram (DCT) as well as (DDCT) to human plasma proteins has to do with 80 %.

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